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BCG Vaccine ‘Trains’ Immunity Through Lasting Epigenetic Rewiring
The Bacillus Calmette‑Guérin (BCG) vaccine, in use for nearly a century to protect against tuberculosis, has long intrigued scientists for its ability to confer non‑specific protection against other infections. A new study led by the Centre for Individualised Infection…
Lower Saxony honors the life's work of Professor Michael Manns
‘It is a particular pleasure for me to honour Professor Michael Manns with the Grand Cross of the Order of Merit of Lower Saxony. This is in recognition of an impressive life's work and a sign of our appreciation for an outstanding and highly renowned scientist in our…
Why the flu vaccine is less effective in older people
Every year at the beginning of October, the flu epidemic rolls around. “Because older people in particular have an increased risk of a severe course of the disease, effective vaccines are especially important for them,” says Prof. Yang Li, Scientific Director of the…
Lyme disease: Probability of developing the disease is genetically predisposed
If a tick is infected with the pathogen Borrelia burgdorferi s. l. (sensu lato = in the broader sense), these bacteria can be transmitted to humans through a tick bite and cause illness. Various organ systems can be affected: the skin, the nervous system or the joints.…
CiiM Founders' Award given to Michael Manns
Prof. Dr. Michael Manns took on the role of founding director in 2015, thereby formally launching CiiM. Under his leadership and in close cooperation with the then managing director of the Helmholtz Centre for Infection Research, Prof. Dr. Dirk Heinz, crucial funding…
‘The star is the team!’
Full support from the state of Lower Saxony After the welcoming remarks by Dean of Research Professor Frank Bengel, Professor Hilfiker-Kleiner and Professor Manns were greeted with thunderous applause. Lower Saxony's Minister of Science Falko Mohrs emphasised that it…
New Research Center for Artificial Intelligence and causal methods in Medicine
The digitalization of the life sciences opens up completely new potential for tackling common diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases such as Alzheimer's. The Center therefore focuses on linking research data, clinical…
COVID-19 Patientenkohorte hilft bei Aufklärung des Patientenrisikos
Aus der MHH stammen Bioproben und Daten der „ COVID-19-Kohorte “, die seit März 2020 von unterschiedlich stark am Coronavirus SARS-CoV-2 erkrankten Patientinnen und Patienten sowie Kontrollproben von Menschen mit anderen Atemwegserkrankungen aus verschiedenen…
Joint symposium of HZI and McGill University on personalised infection medicine
Personalised infection medicine aims to take into account individual differences in the diagnosis and therapy of infectious diseases. The HZI and McGill University have been building a strategic cooperation on this topic for several years. Clinicians and scientists from…
Who benefits from immunotherapy against hepatitis B?
It is estimated that more than 250 million people worldwide are chronically infected with the hepatitis B virus. Cytotoxic T cells and T helper cells play an important role in fighting viral infections. The constant activation of these immune cells in chronically…
The path to personalised hepatitis D treatment
Hepatitis D is caused by coinfection of hepatitis B patients with the hepatitis D virus (HDV). Up to 20 Million individuals are infected with HDV worldwide including about 250.000 patients in the European Union. There is very limited knowledge on disease pathophysiology…
When the skin aches
It was already known that in both psoriasis and neurodermatitis, T-cells of the immune system migrate from the blood into the skin and drive the inflammation there. Detailed examination of T-cells in blood and skin now led to evidence that in atopic dermatitis they…
A virus lurking in the connective tissue
As part of the new study, Dr Katarzyna Sitnik, then working in the “Viral Immunology” department at the HZI, headed by Prof Luka Cicin-Sain, and her colleagues naturally infected mice with murine CMV (mCMV). This variant of the virus is used because human CMV (HCMV) is…
Five HZI scientists are “Highly-cited Researchers”
Bioinformatician Prof Alice McHardy uses computational techniques to research the human microbiome as well as viral and bacterial pathogens. She heads the department “Computational Biology for Infection Research” at BRICS (Braunschweig Integrated Center of Systems…
Hijacking in the immune system
Up to 90% of the world's population carries HCMV. In people with a normal immune system, the infection is usually subclinical, i.e. it does not cause any pronounced symptoms. However, in immunocompromised patients, such as organ transplant recipients, the infection can…
MHH Professor Tobias Welte passed away
Welte was a highly valued partner and colleague to many researchers at the HZI. Particularly close collaborations with Tobias Welte existed, for example, with the HZI "Epidemiology" department under the direction of Prof. Gérard Krause (now WHO) and currently Dr. Berit…
“Aging Clock” reveals aging processes in immune cells
As we age, our immune system also ages. We become more susceptible to infections, vaccinations work less well and the risk of developing immune-related disorders such as autoimmune diseases increases. “In order to better understand how and where exactly the immune…
ERC Proof of Concept Grant for Yang Li
“Prof. Dr. Yang Li impressively combines insights from the life sciences and data science in her research. In doing so, she is laying the foundation for new possibilities for individually adapted diagnoses and therapies in medicine. As head of the Centre for…
What leads to severe COVID-19?
The team was able to identify underlying regulators of the malfunction of the innate immune system in COVID-19 patients and confirm that certain already known genetic risk loci play a role in the development of COVID-19. The results have been published in the journal…
Groundbreaking for the Centre for Individualised Infection Medicine (CiiM)
"The COVID-19 pandemic has just shown us how important infection research and personalised medicine are - and that research findings need to to be transferred more quickly from bench to bedside," said Lower Saxony's Science Minister Falko Mohrs. “The life sciences are…
Comorbidities in HIV: Big data study reveals molecular links
“People with HIV often suffer from non-AIDS-related comorbidities such as cardiovascular disease, liver disease, or cancer. They are more prone to chronic inflammation in the body, which causes them to age faster and have a lower life expectancy than other people,” says…
Team
Team Since its foundation in 2015, the CiiM has grown continuously and coordinative and administrative teams have been created alongside the research groups . Management Prof Dr Yang Li CiiM Director - CiiM Computational Biology for Individualised Medicine…
Ciim | Partner
About us A strong network for the requirements of Individualized Infection Medicine. The embedding of CiiM in the region's existing research network ensures access to patients, interdisciplinary expertise and state-of-the-art technology. Through the…
Organisation
The Structure of the CiiM The CiiM is a joint scientific institution (§ 36 NHG) formed by the founding partners HZI and MHH and was established in 2015 with the signing of a Letter of Intent. The basic principles of the collaboration at CiiM are governed by…
Jobs
Jobs © AdobeStock_294726409 Initiativbewerbungen Become part of the team We are always interested in receiving applications from motivated candidates. More © Adobe Stock/Jelena Job advertisement Building technician (m/f/d) The position of a building…
Centre for Individualised Infection Medicine
Centre for Individualised Infection Medicine The CiiM, based in Hannover, is a joint research institute of the Helmholtz Centre for Infection Research and the Hannover Medical School. More about the CiiM What is individualised medicine? For some years now,…
Centre for Individualised Infection Medicine
Center for Individualised Infection Medicine The CiiM ( Centre for Individualised Infection Medicine ) is a joint initiative of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Hannover Medical School (MHH). The research groups…
Our program
Our program Realising innovation Infections and their sequelae continue to account for one in five deaths worldwide. In this context, emerging and recurrent pathogens, chronic infections, as well as increasing resistance to approved drugs, continue to pose…
Research Groups
The groups at CiiM Four research groups of the HZI and the MHH are currently directly assigned to CiiM and are housed in TWINCORE until the new building is commissioned. In addition, other professorships at MHH (some as joint appointments with HZI) are…
Computational Biology for Individualised Medicine
Infections are among the biggest threats to health and the most significant causes of death worldwide. Our aim is to reveal the host genetic risk factors and their downstream molecular pathways, which are crucial to make progress in understanding and treating infectious diseases in an individualised manner as well as to improve the identification of patients at risk. The department of the HZI is part of the developing CiiM and currently housed at the TWINCORE in Hannover. Students and postdocs – We are always looking for bright and enthusiastic students and postdocs (funded by e.g. the ERC starting grant). For more about our projects, please contact us by email.
Field of research
Field of research Individualized medicine Medicine has always strived to understand the specifics of each patient in order to provide the best possible individualized treatment. In this context, it has become increasingly clear in recent years that the…
Selected projects
Selected projects On the way to individualized infection medicine In various projects, the research groups of CiiM, but also groups of HZI, MHH and TWINCORE are dedicated to different questions in the field of infection medicine and lay important…
The CiiM mourns the loss of its founding director Prof. Michael Manns
"With Michael Manns, we have lost the initiator and architect of the CiiM. He pursued the vision of individualized infectious disease medicine with determination and created structures that form the basis of our work today. For me personally, he was a mentor, advisor,…
Location & Building
Location & Building A Designated Building for Individualized Infection Medicine The Location Hannover - Braunschweig is one of the most important German research regions in the field of infectiology. The close partnership between the HZI in Braunschweig and…
Media Centre
Media Centre Here you can download CiiM information material. We would also be happy to send you the copies you would like by post. Please order them by E-Mail or phone +49 511 22002 7226. CiiM flyer pdf (1.52 MB) Contact Dr Jennifer Debarry Head of Office…
