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CiiM Lecture Series
Event Archive CiiM Lecture Series Internationally renowned scientists from the field of Personalised Medicine are invited to the CiiM Lecture Series. It aims to bring together all scientists and doctors interested in personalised medicine from the various…
Event Archive
Event Archive CiiM Lecture Series Herrenhausen Symposium "Individualised Infection Medicine: The Future is Now" 25. Impfsymposium
Media Centre
Media Centre Mediathek Here you can download CiiM information material. We would also be happy to send you the copies you would like by post. Please order them by E-Mail or phone +49 511 22002 7226. Flyer CiiM-Flyer-EN-web_190909.pdf pdf (1.52 MB) Contact…
What is Individualised Medicine?
What is Individualised Medicine? Topics What is Individualised Medicine? In medicine, the development and application of therapies with maximum efficacy and minimum side effects remains a fundamental challenge. In fact, approved therapies and medicines…
Topics
Topics What is Individualised Medicine? Facets and added value of Individualised Medicin Characteristics of Individualised Infection Medicine
COVID-19 Patient Cohort
COVID-19 Patient Cohort Understanding individual risk and predictability of severe COVID-19 CiiM is involved in the establishment of a COVID-19 patient cohort. The project, led by Prof. Dr. Thomas Illig from the Hannover Unified Biobank (MHH), is funded by…
NUM
NUM Local Coordination Units (LCU) of the Network of University Medicine (NUM) Providing patients with optimal care, preventing infections and expanding healthcare is the mission statement of the Network of University Medicine (NUM), which was founded in…
SARS-CoV-2 Research
SARS-CoV-2 Research Forschung SARS-CoV-2 Research The research groups at CiiM are collaborating to address various current issues in SARS-CoV-2 research. The very diverse clinical histories suggest that a mixture of epidemiological, genetic, and…
Project D-Solve
D-SOLVE EU-Project Logo D-SOLVE The path to personalised hepatitis D treatment Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. However, there is very limited…
Selected projects
Selected projects Research On the way to individualized infection medicine In various projects, the research groups of CiiM, but also groups of HZI, MHH and TWINCORE are dedicated to different questions in the field of infection medicine and lay important…
Our program
Our program Research Realising innovation Infections and their sequelae continue to account for one in five deaths worldwide. In this context, emerging and recurrent pathogens, chronic infections, as well as increasing resistance to approved drugs, continue…
Field of research
Field of research Research Individualized medicine Medicine has always strived to understand the specifics of each patient in order to provide the best possible individualized treatment. In this context, it has become increasingly clear in recent years that…
Ciim | Partner
Partner About us A strong network for the requirements of Individualized Infection Medicine. The embedding of CiiM in the region's existing research network ensures access to patients, interdisciplinary expertise and state-of-the-art technology. Through the…
Update Construction
Update Construction Location & Building Construction schedule and current work in progress In the following, we provide information on the planned construction process and current work in progress. Status August 2024 Current work in progress until December…
Organisation
Organisation About us The Structure of the CiiM The CiiM is a joint scientific institution (§ 36 NHG) formed by the founding partners HZI and MHH and was established in 2015 with the signing of a Letter of Intent. The basic principles of the collaboration…
Centre for Individualised Infection Medicine
The CiiM About us Center for Individualised Infection Medicine The CiiM ( Centre for Individualised Infection Medicine ) is a joint initiative of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Hannover Medical School (MHH). The…
Location & Building
Location & Building About us A Designated Building for Individualized Infection Medicine The Location Hannover - Braunschweig is one of the most important German research regions in the field of infectiology. The close partnership between the HZI in…
Herrenhausen Symposium
Event Archive Herrenhausen Symposium Individualised Infection Medicine: The Future is Now Infektionen sind nach wie vor eine der Haupttodesursachen weltweit. Individuell zugeschnittene Vorsorge und Therapien versprechen neue Heilungsmöglichkeiten. Wie aber…
Individualised Medicine for Viral Infections
Opportunistic infections remain a serious threat to immunocompromised individuals, such as transplant recipients. We study opportunistic herpes viruses, such as the cytomegalovirus (CMV) by developing unique technologies for real-time measurement of virus growth, allowing us rapid identification of antiviral activity of primary samples and virtually any immune cell subset. This allows us to identify at-risk populations and develop targeted antiviral therapies for treatment and prevention of opportunistic viral infections. In the course of the COVID pandemic, our expertise in virus genetics was used to clone pseudoviruses expressing variants of the SARS-CoV-2 spike protein for the assessment of the neutralization capacity of sera or monoclonal antibodies, and this technology is pursued in the identification of correlates of immune protection in vaccinated or convalescent populations. We team with local and international teams of physicians and epidemiologists, providing technical support and scientific advice on complex laboratory serological diagnostics. In March 2019, Prof Dr. Dr. Luka Cicin-Sain was jointly appointed by the MHH (Hannover Medical School) and HZI (Helmholtz Centre for Infection Research) as CIIM Professor for "Individualised Medicine of Viral Infections", and as of 2021 he leads the CiiM-associated Department of “Viral Immunology” (VIRI) at the Helmholtz Centre for Infection Research in Braunschweig.
Infection Biology
Microbial communities consisting of bacteria, fungi and viruses colonize all surfaces of the human body. They are referred to in their entirety as the microbiome. The composition of the microbiome varies between individuals and also within an individual in the course of life. Important influencing factors at the beginning of life are the mode of birth and diet, later the intake of antibiotics and medication as well as long-term diets, the state of health, but also sport and stress play a role. In recent years, a large number of studies have begun to investigate the extent to which the microbiome and its changes actively contribute to our health and the development of diseases. For various diseases, it has been shown in animal models and clinical studies that certain changes in the microbiome influence either the development or the course of e.g. chronic inflammatory bowel diseases or susceptibility to infections. This has led to the development of novel microbiome-based therapies that are currently being investigated in animal models and clinical studies. Prof. Strowig's department uses interdisciplinary approaches from microbiological, immunological and bioinformatic methods to gain a molecular understanding of the complex interactions between the intestinal microbiome and the host. The knowledge that can be gained from this forms an important cornerstone for the development of new individual prevention and therapy approaches. The close cooperation between the MHH and HZI at the CiiM will enable research results from basic research to be transferred more directly into practice in the future. One example is the successful establishment of a microbiome analysis platform, which is essential for researching the influence of the host's microbiome on its susceptibility to infections and has already been used for various patient cohorts (RESIST-SeniorIndividuals, LöwenKIDS). Another example is the identification of specific microbiome components that can be used in preclinical models to prevent colonization with disease-promoting bacteria.
Computational Biology for Infection Research
The group studies microbial communities, including bacteria, viruses and eukaryotic community members, in the context of human health and disease. Direct metagenome, -transcriptome or -proteome sequencing of microbial community samples enables the study of microorganisms that cannot be obtained in pure culture, corresponding to most of the microbial world.
CAIMed Group 1b: AI and Bioinformatics
The identification of genetic risk factors and their molecular signaling pathways as well as the development of predictive models for disease progression and severity are crucial for progress in the understanding and individualized treatment of diseases. At the MHH, existing and planned patient cohorts with state-of-the-art (single-cell) multi-omics data are available. The bioinformatics junior research group will focus on the pre-processing of molecular data in order to create standardized data sets for the analyses of the other CAIMed junior research groups. The aim is to integrate this data on an unprecedented scale using innovative AI methods. These include the identification of factors that correlate with disease severity and progression using causal inference methods. Furthermore, the investigation of cell type-specific genetic effects on molecular characteristics will be carried out using the "deconvolution" method. Finally, mathematical models such as support vector machines will be developed to predict individual reactions to diseases/treatments and thus create a molecular basis for the stratification of patient groups. The aim is to promote the implementation of these mathematical models in medical treatment or diagnostic procedures as a crucial first step towards individualized prevention. Close cooperation with the Integrative Multi-Omics Data group is planned.
Prof Dr Yang Li
Prof Dr Yang Li CiiM Director - CiiM +49 511 220027200 E-Mail Yang Li has headed the Department of Computational Biology for Individualised Medicine at the CiiM and the HZI since 2019 and was also appointed Director of the CiiM. The focus of her research is…
Imprint
Imprint according to the following German regulations: § 6 TDG, § 10 MDStV Publisher Helmholtz-Zentrum für Infektionsforschung GmbH (Helmholtz Centre for Infection Research) Inhoffenstraße 7 38124 Braunschweig Telefon: 0531 6181-0 Telefax: 0531 6181-2655…
Immunology of Viral Hepatitis and Infections in Liver Cirrhosis
Hepatitis viruses A-E pose a major health challenge worldwide. Acute infections with hepatitis B (HBV), C (HCV), D (HDV) or E (HEV) can progress to chronic hepatitis and lead to liver cirrhosis and hepatocellular carcinoma. Chronic viral hepatitis affects more than 350 million people worldwide. While direct-acting antiviral drugs provide a cure for chronic hepatitis C, the long-term effects on the immune system after the infection is cured are not fully understood. While direct-acting antiviral nucleos(t)ide analogues can treat chronic hepatitis B, complete cure is rare. Innovative approaches, particularly modulation of the immune response to HBV, hold promise for a cure. Chronic hepatitis D is always a co-infection with HBV and thus concepts to cure HBV will also target HDV. In chronic hepatitis E, which is unique in immunocompromised patients such as organ transplant patients, enhancing the immune response against HEV may be a novel strategy. In people with cirrhosis of the liver, regardless of the cause, the immune system is compromised and susceptibility to infection is increased. In particular, bacterial infections of the peritoneal cavity due to ascites contribute significantly to disease progression. Our research group focuses on understanding immune responses to hepatitis viruses and developing biomarkers to better stratify patients for new therapeutic strategies to modulate the host immune system in the effort to combat chronic viral hepatitis. In addition, we are exploring the mechanisms underlying immunodeficiency in liver cirrhosis and investigating immunomodulation strategies to improve survival in these vulnerable patients.
Data protection
Data protection Data protection Thank you for your interest in our website. The Helmholtz Centre for Infection Research (HZI) takes the protection of personal data very seriously. It is possible to use our website without providing any personal data. This…
Centre for Individualised Infection Medicine
Centre for Individualised Infection Medicine The CiiM, based in Hannover, is a joint research institute of the Helmholtz Centre for Infection Research and the Hannover Medical School. More about the CiiM What is individualised medicine? For some years now,…
Personalised Immunotherapy
Our motivation is to address fundamental questions of human immunology and translate them into personalized therapies and diagnostics. Specifically, our laboratory discovers new applications of antibodies and B cells to treat and prevent human infectious diseases. Effective vaccines against some viruses that escape antibody responses remain elusive. To tackle this challenge, we develop methods to better understand B cell responses, the cells that produce antibodies. We design tailored vaccines and provide novel solutions for infection diagnostics.
Clinical Bioinformatics
Personalized medicine offers a significant opportunity to enhance public health by accounting for individual variability in genes, environment, and lifestyle. The "Clinical Bioinformatics" research group follows this direction, aiming to unravel the intricate molecular mechanisms underlying infection and aging. Through this pursuit, we strive to develop precise, individualized treatment strategies. Our research aims to develop and apply "bioinformatics approaches" to pinpoint the genetic and epigenetic factors influencing infection-induced immune responses by integrating multi-omics data from patients and constructing computational models that predict an individual’s risk of infectious diseases. We interact with experimental collaborators and clinical experts to verify our findings and promote their translation into medical treatments or diagnostic procedures. Our ultimate goal is to contribute to the main research focus of CiiM/MHH: the tailored and improved prevention, diagnosis, and treatment of infectious diseases and cancer for individual patients or patient groups. Within this framework, the team led by Prof. Dr. Cheng-Jian Xu is primarily dedicated to the domains of diagnosis, risk assessment, early detection, and patient stratification.
Computational Biology for Individualised Medicine
Infections are among the biggest threats to health and the most significant causes of death worldwide. Our aim is to reveal the host genetic risk factors and their downstream molecular pathways, which are crucial to make progress in understanding and treating infectious diseases in an individualised manner as well as to improve the identification of patients at risk. The department of the HZI is part of the developing CiiM and currently housed at the TWINCORE in Hannover. Our group currently has 6 PhD students and 5 postdocs. Students and postdocs – We are always looking for bright and enthusiastic students and postdocs (funded by e.g. the ERC starting grant). For more about our projects, please contact us by email.
Jobs at CiiM
Jobs at CiiM Applications Join the team CiiM is growing and the CiiM groups are always happy to receive applications from motivated and qualified candidates. Open job advertisements can be found on the group pages. In addition, speculative applications are…
Characteristics of Individualised Infection Medicine
Characteristics of Individualised Infection Medicine The page is under construction.
Facets and added value of Individualised Medicine
Facets and added value of Individualised Medicine The page is under construction.
Events
Events Scientific 30 January 2025 1.00 pm CAIMed Meet-up AI Powered Approaches in Infection Research Host: TWINCORE Show more events Show all events
Jobs
Jobs © AdobeStock_294726409 Initiativbewerbungen Become part of the team We are always interested in receiving applications from motivated candidates. More © HZI PhD Program Initiative "Curiosity is infectious" With the initiative “Curiosity is infectious”,…
Team
Team Since its foundation in 2015, the CiiM has grown continuously and coordinative and administrative teams have been created alongside the research groups .
Senior Professorship Manns
Prof. Manns' senior professorship of the State of Lower Saxony supports the development and scientific organisation of the CiiM, whereby the integration of the MHH and HZI working groups as well as the core facilities and foundations is driven forward. The focus is on the development of patient-oriented concepts of personalised infection medicine, the expansion of national and international networks and the acquisition of third-party funding.
Research Groups
Research The groups at CiiM Four research groups of the HZI and the MHH are currently directly assigned to CiiM and are housed in TWINCORE until the new building is commissioned. In addition, other professorships at MHH (some as joint appointments with HZI)…
Prof Dr Markus Cornberg
Prof Dr med. Markus Cornberg CiiM Director - CiiM +49 511 532 6821 E-Mail Markus Cornberg is W3-Professor Infectious Diseases with a focus on Hepatology and Deputy Director of the Department of Gastroenterology, Hepatology, Infectious Diseases and…
