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Immunology of Viral Hepatitis and Infections in Liver Cirrhosis
Hepatitis viruses A-E pose a major health challenge worldwide. Acute infections with hepatitis B (HBV), C (HCV), D (HDV) or E (HEV) can progress to chronic hepatitis and lead to liver cirrhosis and hepatocellular carcinoma. Chronic viral hepatitis affects more than 350 million people worldwide. While direct-acting antiviral drugs provide a cure for chronic hepatitis C, the long-term effects on the immune system after the infection is cured are not fully understood. While direct-acting antiviral nucleos(t)ide analogues can treat chronic hepatitis B, complete cure is rare. Innovative approaches, particularly modulation of the immune response to HBV, hold promise for a cure. Chronic hepatitis D is always a co-infection with HBV and thus concepts to cure HBV will also target HDV. In chronic hepatitis E, which is unique in immunocompromised patients such as organ transplant patients, enhancing the immune response against HEV may be a novel strategy. In people with cirrhosis of the liver, regardless of the cause, the immune system is compromised and susceptibility to infection is increased. In particular, bacterial infections of the peritoneal cavity due to ascites contribute significantly to disease progression. Our research group focuses on understanding immune responses to hepatitis viruses and developing biomarkers to better stratify patients for new therapeutic strategies to modulate the host immune system in the effort to combat chronic viral hepatitis. In addition, we are exploring the mechanisms underlying immunodeficiency in liver cirrhosis and investigating immunomodulation strategies to improve survival in these vulnerable patients.
Computational Biology for Infection Research
The group studies microbial communities, including bacteria, viruses and eukaryotic community members, in the context of human health and disease. Direct metagenome, -transcriptome or -proteome sequencing of microbial community samples enables the study of microorganisms that cannot be obtained in pure culture, corresponding to most of the microbial world.
D-Solve
D-SOLVE EU-Project Logo D-SOLVE The path to personalised hepatitis D treatment Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. However, there is very limited…
Prof Dr Yang Li
Prof Dr Yang Li CiiM Director - CiiM +49 511 220027200 E-Mail Yang Li has headed the Department of Computational Biology for Individualised Medicine at the CiiM and the HZI since 2019 and was also appointed Director of the CiiM. The focus of her research is…
Prof Dr Markus Cornberg
Prof Dr Markus Cornberg CiiM Director - CiiM +49 511 532 6821 E-Mail Markus Cornberg is W3-Professor Infectious Diseases with a focus on Hepatology and Deputy Director of the Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology…
Update Construction
Update Construction Location & Building Construction schedule and current work in progress In the following, we provide information on the planned construction process and current work in progress. Status August 2024 Current work in progress until December…
The CiiM
The CiiM About us Center for Individualised Infection Medicine The CiiM ( Centre for Individualised Infection Medicine ) is a joint initiative of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Hannover Medical School (MHH). The…
Jobs
Jobs © AdobeStock_294726409 Initiativbewerbungen Become part of the team We are always interested in receiving applications from motivated candidates. More © HZI/Verena Meier Job advertisement Postdoc with focus on translational activities (m/w/d) The PERI…
Herrenhausen Symposium
Event Archive Herrenhausen Symposium Individualised Infection Medicine: The Future is Now Infektionen sind nach wie vor eine der Haupttodesursachen weltweit. Individuell zugeschnittene Vorsorge und Therapien versprechen neue Heilungsmöglichkeiten. Wie aber…
Imprint
Imprint according to the following German regulations: § 6 TDG, § 10 MDStV Publisher Helmholtz-Zentrum für Infektionsforschung GmbH (Helmholtz Centre for Infection Research) Inhoffenstraße 7 38124 Braunschweig Telefon: 0531 6181-0 Telefax: 0531 6181-2655…
