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Infection with SARS-CoV-2 leads to severe disease in some people, whereas others do not get ill or only experience mild disease. What causes these differences is not fully understood. It is already known that an overactive innate immune system is causing severe COVID-19 disease, but it is unclear how this is regulated. A team led by Prof Yang Li, Director at the Centre for Individualised Infection Medicine (CiiM) and head of department “Computational Biology for Individualised Medicine” at the Helmholtz Centre for Infection Research (HZI), has come a step closer to answering this question. The researchers addressed the question to what extent the course of disease is genetically or epigenetically regulated. The CiiM is a joint initiative by the HZI and Hannover Medical School (MHH). In addition to Li, the team included other scientists from the HZI and the RESIST cluster of excellence.

A dedicated building is being constructed in Hannover for the Centre for Individualised Infection Medicine (CiiM), a joint initiative of the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH). The groundbreaking ceremony for the new building with 2100 square metres of effective space was held today in the presence of numerous guests from politics and science. CiiM, which was initially founded in 2015 as a virtual centre, is addressing urgent challenges in infectious medicine with the aim of individual prognosis and diagnosis of infectious diseases and derived optimised and customised prevention and personalised therapy for the benefit of the individual patient. The construction costs are covered by the federal government, the state of Lower Saxony, the Helmholtz Association and the HZI.

Many people suffer from neurodermatitis (atopic dermatitis) or psoriasis. These chronic inflammatory diseases, which have so far been incurable, can lead to a significant loss of quality of life due to the agonising itching and stigmatisation in severe forms. Researchers of the exzellence cluster RESIST have now gained a number of new insights with potential clinical relevance using state-of-the-art technologies such as T-cell receptor and single-cell RNA sequencing based on skin biopsies and blood samples from patients. They have published these in the journal Allergy, currently the leading publication in the field of allergology, in two articles. The main authors include Dr Bowen Zhang from the research group of Prof Yang Li, Centre for Individualised Infection Medicine (CiiM) and TWINCORE - Centre for Experimental and Clinical Infection Research, and Dr Lennart Rösner and Dr Stephan Traidl from the team of Prof Thomas Werfel, Clinic for Dermatology, Allergology and Venereology at Hanover Medical School (MHH). The CiiM and TWINCORE are joint institutions of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and MHH.

Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. However, there is very limited knowledge on disease pathophysiology and host-virus interactions explaining the large interindividual variability in the course of hepatitis D. Hannover Medical School (MHH) with its Department of Gastroenterology, Hepatology and Endocrinology and its Centre for Individualised Infection Medicine (CiiM), a joint institution of MHH and the Helmholtz Centre for Infection Research (HZI) in Braunschweig, coordinates an international project for an unbiased screening of a large multicenter cohort of well-defined HDV-infected patients to better understand individual factors determining the outcome of infection and to identify subjects benefitting from currently available treatments. In a highly competitive call for proposals, the D-SOLVE consortium (“Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D”) has received four-year funding of 6.75 million euros from the Horizon 2020 EU Horizon Call „Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2)“ of the European Union. In addition to the MHH as project partner and coordinator, institutions from Germany, France, Italy, Sweden and Romania are involved in the project.

Hepatitis B is a viral infection of the liver that can lead to cancer and organ failure. Antiviral therapies can suppress the infection, but a functional cure is rare. Novel immunotherapies may lead to an actual cure more often. However, it is still unclear which patients benefit most from these new therapies. Researchers at the Centre for Individualised Infection Medicine (CiiM), a joint institution of the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), as well as the MHH and the German Center for Infection Research (DZIF), have now identified a biomarker that intends to enable predictions about the success of the therapy. The results were published in the scientific journal Gut.

The Helmholtz Centre for Infection Research (HZI) in Braunschweig and the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) at McGill University in Montréal, Canada, are organising a joint symposium on personalised infection medicine on 29 November. Three researchers from each of the two institutions will give lectures on various topics of personalised infection medicine. The keynote lecture will be given by Prof Ugur Sahin, co-founder and CEO of BioNTech SE. The symposium kicks off McGill University's “Infection and Immunity Week”, which celebrates its 200th anniversary this year. Interested scientists can register to follow the event online.