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SARS-CoV-2 Research


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Publications

Research

New research findings from CiiM

In the following you will find publications with CiiM participation (as of March 2020):

2020

Alfonso JCL, Papaxenopoulou LA, Mascheroni P, Meyer-Hermann M, Hatzikirou H. On the Immunological Consequences of Conventionally Fractionated Radiotherapy. iScience. 2020;23(3):100897.

Cornberg M, Lok AS, Terrault NA, Zoulim F, Faculty E-AHTEC. Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference(double dagger). J Hepatol. 2020;72(3):539-557.

de Araujo LS, Pessler K, Suhs KW, et al. Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis. J Transl Med. 2020;18(1):9.

Licht MK, Nuss AM, Volk M, et al. Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus. Microorganisms. 2020;8(2).

Montaseri G, Alfonso JCL, Hatzikirou H, Meyer-Hermann M. A minimal modeling framework of radiation and immune system synergy to assist radiotherapy planning. J Theor Biol. 2020;486:110099.

Niehaus CE, Strunz B, Cornillet M, et al. MAIT cells are enriched and highly functional in ascites of patients with decompensated liver cirrhosis. Hepatology. 2020.

Prinz I, Sandrock I, Mrowietz U. Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment. J Exp Med. 2020;217(1).

Qi C, Jiang Y, Yang IV, et al. Nasal DNA methylation profiling of asthma and rhinitis. J Allergy Clin Immunol. 2020.

Rinker F, Bremer CM, Schroder K, et al. Quantitation of large, middle and small hepatitis B surface proteins in HBeAg-positive patients treated with peginterferon alfa-2a. Liver Int. 2020;40(2):324-332.

Samir M, Vidal RO, Abdallah F, et al. Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1). RNA Biol. 2020;17(1):112-124.

Sebestyen Z, Prinz I, Dechanet-Merville J, Silva-Santos B, Kuball J. Translating gammadelta (gammadelta) T cells and their receptors into cancer cell therapies. Nat Rev Drug Discov. 2020;19(3):169-184.

Vermeulen CJ, Xu CJ, Vonk JM, et al. Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission. Eur Respir J. 2020;55(2).

Zorro MM, Aguirre-Gamboa R, Mayassi T, et al. Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. J Autoimmun. 2020;108:102422.

2019

Akmatov MK, Riese P, Trittel S, et al. Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly. BMC Infect Dis. 2019;19(1):656.

Aregay A, Owusu Sekyere S, Deterding K, et al. Elimination of hepatitis C virus has limited impact on the functional and mitochondrial impairment of HCV-specific CD8+ T cell responses. J Hepatol. 2019;71(5):889-899.

Arshad H, Alfonso JCL, Franke R, et al. Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia. J Transl Med. 2019;17(1):365.

Arulraj T, Binder SC, Robert PA, Meyer-Hermann M. Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses. Front Immunol. 2019;10:2116.

Chen F, Lukat P, Iqbal AA, et al. Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A. 2019;116(41):20644-20654.

Cicin-Sain L. Cytomegalovirus memory inflation and immune protection. Med Microbiol Immunol. 2019;208(3-4):339-347.

Cornberg M, Lok AS, Terrault NA, Zoulim F, Faculty E-AHTEC. Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference. Hepatology. 2019.

Cornberg M, Suk-Fong Lok A, Terrault NA, Zoulim F, Berg E-AHTECF. Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference. J Hepatol. 2019.

de Araujo LS, Ribeiro-Alves M, Leal-Calvo T, et al. Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection. mBio. 2019;10(6).

Kimmann M, Tergast TL, Schultalbers M, et al. Sustained impact of nosocomial-acquired spontaneous bacterial peritonitis in different stages of decompensated liver cirrhosis. PLoS One. 2019;14(8):e0220666.

Mascheroni P, Lopez Alfonso JC, Kalli M, Stylianopoulos T, Meyer-Hermann M, Hatzikirou H. On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas. Cancers (Basel). 2019;11(5).

Meyer-Hermann M. Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies. Cell Rep. 2019;29(5):1066-1073 e1065.

Prinz I, Sandrock I. Dangerous gammadelta T cells in aged mice. EMBO Rep. 2019;20(8):e48678.

Prinz I, Sandrock I, Mrowietz U. Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment. J Exp Med. 2019.

Qi C, Xu CJ, Koppelman GH. The role of epigenetics in the development of childhood asthma. Expert Rev Clin Immunol. 2019:1-16.

Ratuszny D, Suhs KW, Novoselova N, et al. Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis. Int J Mol Sci. 2019;20(2).

Rinker F, Bremer CM, Schroder K, et al. Quantitation of large, middle and small hepatitis B surface proteins in HBeAg-positive patients treated with peginterferon alfa-2a. Liver Int. 2019.

Samir M, Vidal RO, Abdallah F, et al. Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1). RNA Biol. 2019:1-13.

Schlicker L, Boers HM, Dudek CA, et al. Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans. Metabolites. 2019;9(5).

Sebestyen Z, Prinz I, Dechanet-Merville J, Silva-Santos B, Kuball J. Translating gammadelta (gammadelta) T cells and their receptors into cancer cell therapies. Nat Rev Drug Discov. 2019.

Sharma-Chawla N, Stegemann-Koniszewski S, Christen H, et al. In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection. Front Immunol. 2019;10:1864.

Soon CF, Behrendt P, Todt D, et al. Defining virus-specific CD8+ TCR repertoires for therapeutic regeneration of T cells against chronic hepatitis E. J Hepatol. 2019;71(4):673-684.

Soon CF, Zhang S, Suneetha PV, et al. Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy. Front Immunol. 2019;10:2076.

Suhs KW, Novoselova N, Kuhn M, et al. Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections. J Infect Dis. 2019.

Tergast TL, Kimmann M, Laser H, et al. Systemic arterial blood pressure determines the therapeutic window of non-selective beta blockers in decompensated cirrhosis. Aliment Pharmacol Ther. 2019;50(6):696-706.

Vermeulen CJ, Xu CJ, Vonk JM, et al. Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission. Eur Respir J. 2019.

Wiegand SB, Beggel B, Wranke A, et al. Soluble immune markers in the different phases of chronic hepatitis B virus infection. Sci Rep. 2019;9(1):14118.

Ynga-Durand MA, Dekhtiarenko I, Cicin-Sain L. Vaccine Vectors Harnessing the Power of Cytomegaloviruses. Vaccines (Basel). 2019;7(4).

 

2018

Cornberg M, Manns MP. Hepatitis: No cure for hepatitis B and D without targeting integrated viral DNA? Nat Rev Gastroenterol Hepatol. 2018;15(4):195-196.

Honer Zu Siederdissen C, Bjorkstrom NK, Cornberg M. Reply to Liaw. J Infect Dis. 2018;218(11):1853-1854.

Khailaie S, Rowshanravan B, Robert PA, et al. Characterization of CTLA4 Trafficking and Implications for Its Function. Biophys J. 2018;115(7):1330-1343.

Kuhn M, Suhs KW, Akmatov MK, et al. Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. J Neuroinflammation. 2018;15(1):20.

Loof TG, Sohail A, Bahgat MM, et al. Early Lymphocyte Loss and Increased Granulocyte/Lymphocyte Ratio Predict Systemic Spread of Streptococcus pyogenes in a Mouse Model of Acute Skin Infection. Front Cell Infect Microbiol. 2018;8:101.

Meyer-Hermann M, Binder SC, Mesin L, Victora GD. Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers. Front Immunol. 2018;9:2020.

Meyer-Hermann M. Estimation of the cancer risk induced by therapies targeting stem cell replication and treatment recommendations. Sci Rep. 2018;8(1):11776.

Montaseri G, Boianelli A, Hernandez-Vargas EA, Meyer-Hermann M. PK/PD-based adaptive tailoring of oseltamivir doses to treat within-host influenza viral infections. Prog Biophys Mol Biol. 2018;139:31-42.

Olmer R, Engels L, Usman A, et al. Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture. Stem Cell Reports. 2018;10(5):1657-1672.

Rinker F, Zimmer CL, Honer Zu Siederdissen C, et al. Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B. J Hepatol. 2018;69(3):584-593.

Tergast TL, Laser H, Gerbel S, Manns MP, Cornberg M, Maasoumy B. Association Between Type 2 Diabetes Mellitus, HbA1c and the Risk for Spontaneous Bacterial Peritonitis in Patients with Decompensated Liver Cirrhosis and Ascites. Clin Transl Gastroenterol. 2018;9(9):189.

Tergast TL, Wranke A, Laser H, et al. Dose-dependent impact of proton pump inhibitors on the clinical course of spontaneous bacterial peritonitis. Liver Int. 2018;38(9):1602-1613.

Wortmann N, Honer Zu Siederdissen C, Cornberg M. [Chronic hepatitis B and D (delta) : Current and future treatments]. Internist (Berl). 2018.

 

2017

Akmatov MK, Koch N, Vital M, et al. Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study - findings from Pretest 1 of the German National Cohort. Sci Rep. 2017;7(1):1855.

Akmatov MK, Riese P, May M, et al. Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population. Hum Vaccin Immunother. 2017:1-10.

Akmatov MK, Jentsch L, Riese P, et al. Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination. BMC Med Res Methodol. 2017;17(1):18.

Bartenschlager R, Cornberg M, Pietschmann T. [Personalized treatment of viral hepatitis of the present and the future : Hepatitis B, C, delta, and E]. Internist (Berl). 2017;58(7):666-674.

 Debarry J, Heinz D, Manns MP. [Individualized infection medicine : Challenges and opportunities]. Internist (Berl). 2017;58(7):647-649.

Filomena A, Pessler F, Akmatov MK, et al. Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori. High Throughput. 2017;6(4).

Karabaev BB, Beisheeva NJ, Satybaldieva AB, Ismailova AD, Pessler F, Akmatov MK. Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015). Infect Dis Poverty. 2017;6(1):45.

Preusse M, Schughart K, Pessler F. Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection. Front Immunol. 2017;8:246.

Rubsamen N, Akmatov MK, Castell S, Karch A, Mikolajczyk RT. Factors associated with attrition in a longitudinal online study: results from the HaBIDS panel. BMC Med Res Methodol. 2017;17(1):132.

Witte T, Pieper DH, Heidrich B. [Intestinal microbiota in individualized therapies]. Internist (Berl). 2017;58(7):682-686.

2016

Cornberg M, Manns MP. Hepatitis C: individualised medicine versus one pill fits all. Lancet Gastroenterol Hepatol. 2016;1(2):86-87.