D-SOLVE

The path to personalised hepatitis D treatment

Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. However, there is very limited knowledge on disease pathophysiology and host-virus interactions explaining the large interindividual variability in the course of hepatitis D. The D-SOLVE consortium ( (“Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D”), coordinated at MHH/CiiM, aims for an unbiased screening of a large multicenter cohort of well-defined HDV-infected patients to better understand individual factors determining the outcome of infection and to identify subjects benefitting from currently available treatments. In a highly competitive call for proposals, the D-SOLVE consortium has received four-year funding of 6.75 million euros from the Horizon 2020 EU Horizon Call „Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2)“ of the European Union.